Lipoprotein Metabolism and Dyslipidemias

A 48-year-old woman is found to have markedly elevated LDL cholesterol (220 mg/dL) and total cholesterol (320 mg/dL) on routine screening. Her triglycerides are 95 mg/dL and HDL-C is 52 mg/dL. She has no personal history of cardiovascular disease but her father died of myocardial infarction at age 55. Physical examination reveals tendon xanthomas on the Achilles tendons and corneal arcus. What is the most appropriate next step?

A 52-year-old man with premature coronary artery disease presents with xanthomas on the Achilles tendon and corneal arcus. Lipid panel shows total cholesterol 480 mg/dL, LDL-C 420 mg/dL, HDL-C 35 mg/dL, triglycerides 150 mg/dL. Which single feature best distinguishes familial hypercholesterolaemia (FH) from familial combined hyperlipidaemia (FCH)?

Which apolipoprotein is the primary structural component of chylomicrons and is synthesized in the intestinal epithelial cells?

A 52-year-old Indian man presents to the outpatient clinic with recurrent premature coronary artery disease (CAD). His father died of MI at age 48. On examination, he has xanthomas on his Achilles tendons and corneal arcus. Lipid profile: Total cholesterol 520 mg/dL, LDL-C 450 mg/dL, HDL-C 35 mg/dL, Triglycerides 150 mg/dL. Genetic testing confirms homozygous familial hypercholesterolaemia (FH). Which of the following mechanisms best explains the markedly elevated LDL-C in this patient?

Regarding the structure and function of lipoproteins, all of the following statements are correct EXCEPT: