Stevens-Johnson Syndrome and TEN

A 28-year-old woman presents with fever, painful oral ulcers, and a widespread blistering rash involving <10% of body surface area. She had started trimethoprim-sulfamethoxazole for a urinary tract infection 2 weeks ago. What is the most common causative drug class implicated in Stevens-Johnson Syndrome?

Which of the following drugs is the MOST common cause of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in India?

A 28-year-old woman presents to the emergency department with widespread painful blistering and mucosal erosions that started 3 days after starting trimethoprim-sulfamethoxazole for a urinary tract infection. Examination reveals erythematous macules and targetoid lesions involving 25% of body surface area, with involvement of oral, ocular, and genital mucosa. Temperature is 38.5°C. What is the most appropriate immediate next step in management?

A 28-year-old woman presents with fever, mucosal erosions, and a rapidly spreading erythematous rash with target lesions involving >30% of body surface area. She had started cotrimoxazole 5 days ago for a urinary tract infection. Which investigation is most specific for confirming the diagnosis of Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis (SJS/TEN)?

A 35-year-old man with fever, mucosal involvement, and >50% body surface area involvement with epidermal detachment is suspected to have Toxic Epidermal Necrolysis (TEN). Which investigation is most appropriate for assessing disease severity and guiding prognostic counselling?