Nasopharyngeal Carcinoma

A 42-year-old male from Tamil Nadu presents with a 3-month history of unilateral epistaxis and cervical lymphadenopathy. Flexible nasopharyngoscopy reveals a mass in the nasopharynx. Biopsy confirms squamous cell carcinoma. CT head and neck shows a 4 cm nasopharyngeal mass with ipsilateral cervical lymph node involvement (N2). There is no evidence of distant metastasis on staging imaging. What is the most appropriate next step in management?

A 52-year-old man from southern India presents with unilateral cervical lymphadenopathy and epistaxis. Nasopharyngoscopy reveals a mass in the nasopharynx. Histopathology confirms malignancy. What is the most common histological type of nasopharyngeal carcinoma?

A 48-year-old man from endemic nasopharyngeal carcinoma region presents with unilateral neck mass and nasal obstruction. Biopsy confirms nasopharyngeal carcinoma. What is the most common site of origin within the nasopharynx?

A 48-year-old woman with biopsy-proven nasopharyngeal carcinoma (undifferentiated squamous cell type) is being staged for treatment planning. She is asymptomatic for distant metastases. Which investigation is most appropriate as the next step to detect occult metastatic disease and guide treatment intensity?

Which histological type accounts for approximately 95% of nasopharyngeal carcinomas worldwide and is strongly associated with Epstein-Barr virus (EBV) infection?