Retinoblastoma

A young child presents with the eye finding shown in the image. Which of the following is the most likely diagnosis?

A 2-year-old boy from rural Maharashtra presents with leukocoria (white pupil reflex) in the left eye noticed by his mother 3 weeks ago. On examination, the child is otherwise healthy with no systemic features. Dilated fundoscopy shows a whitish intraocular mass in the posterior pole. What is the most appropriate next step in management?

A 3-year-old girl with unilateral retinoblastoma is being evaluated for metastatic disease before initiating systemic chemotherapy. Which investigation is most appropriate to detect bone marrow involvement and assess for metastatic disease?

A 2-year-old boy presents with leukocoria (white pupillary reflex) in the right eye noticed by his mother 3 weeks ago. Dilated fundoscopy shows a white intraretinal mass with calcification. What is the investigation of choice to confirm the diagnosis of retinoblastoma and assess for bilateral involvement?

A 3-year-old Indian child with a family history of retinoblastoma is found to have bilateral intraocular masses on screening. Which is the most common genetic abnormality in hereditary retinoblastoma?