Osteoarthritis

Which of the following is the primary pathological hallmark of osteoarthritis?

A 58-year-old man with a 5-year history of right hip osteoarthritis presents with severe pain (VAS 8/10) and significant functional limitation despite 6 months of NSAIDs (naproxen 500 mg BD), physiotherapy, and weight loss of 8 kg. Radiographs show advanced OA with severe joint space narrowing and large osteophytes. He is a candidate for surgery. Before proceeding to total hip arthroplasty, what is the most appropriate next step?

A 62-year-old woman presents with chronic knee pain and morning stiffness lasting 30 minutes. Radiographs show joint space narrowing, osteophytes, and subchondral sclerosis. Which of the following is NOT a characteristic feature of osteoarthritis?

A 62-year-old woman from Delhi presents with a 3-year history of progressive pain and stiffness in both knees, worse in the morning and after prolonged sitting. She has a BMI of 28 kg/m². On examination, there is crepitus on knee flexion-extension, mild swelling, and reduced range of motion. X-ray of both knees shows joint space narrowing, osteophytes at the joint margins, and subchondral sclerosis. She denies any history of trauma or inflammatory arthritis. What is the most likely diagnosis?

A 58-year-old man from Mumbai presents with a 2-year history of progressive pain and swelling in his right hip. He reports pain radiating to the groin and anterior thigh, which worsens with walking and internal rotation of the hip. On examination, there is restricted internal rotation and extension of the right hip. He has a positive FABER test. His ESR is 18 mm/hr and CRP is 2 mg/L. X-ray of the pelvis shows joint space narrowing, osteophytes around the femoral head and acetabulum, and subchondral cyst formation. What is the most appropriate first-line management?