Septic Arthritis

A 35-year-old male presents with acute onset knee pain, swelling, and inability to bear weight. Examination reveals a hot, tense joint with restricted movement. Synovial fluid analysis shows WBC 85,000/μL with 92% neutrophils, glucose 18 mg/dL (serum 110 mg/dL), protein 6.2 g/dL, and positive Gram stain for cocci. Which of the following is NOT a typical feature of septic arthritis?

In a series of 100 cases of acute bacterial septic arthritis in a tertiary care hospital in Delhi, the knee joint was involved in 48 cases, hip in 22 cases, ankle in 15 cases, and shoulder in 10 cases. What is the most common site of septic arthritis?

A 28-year-old woman with a history of intravenous drug use presents with a 5-day history of left shoulder pain, swelling, and fever (38.2°C). Synovial fluid obtained by arthrocentesis shows WBC 62,000/μL (90% neutrophils), glucose 22 mg/dL (serum 110 mg/dL), protein 5.8 g/dL, and Gram stain is negative. Blood cultures are pending. She is allergic to penicillin (anaphylaxis). What is the most appropriate immediate antibiotic regimen?

Which organism is the most common cause of septic arthritis in healthy adults?

What is the gold standard diagnostic test for confirming septic arthritis?