Alcoholic Liver Disease

A 52-year-old male with a 20-year history of heavy alcohol consumption presents with jaundice, ascites, and hepatic encephalopathy. Laboratory investigations show INR 2.8, serum bilirubin 4.2 mg/dL, and albumin 2.1 g/dL. He is diagnosed with decompensated alcoholic cirrhosis. Which drug is the first-line treatment to improve his survival and reduce portal hypertension complications?

A 48-year-old man with alcoholic hepatitis (AST 320 U/L, ALT 180 U/L, bilirubin 5.8 mg/dL, INR 1.9) and a Maddrey discriminant function score of 68 is admitted for management. He denies variceal bleeding or encephalopathy. Which is the drug of choice for reducing mortality in severe alcoholic hepatitis?

In the progression of alcoholic liver disease, which stage is characterized by reversible hepatic steatosis without significant inflammation or fibrosis?

A 48-year-old Indian man with chronic alcohol abuse presents with hepatomegaly and jaundice. Liver biopsy shows hepatocyte steatosis, inflammation, and characteristic cytoplasmic inclusions. What is the most common histologic finding in alcoholic liver disease?

A 48-year-old woman with chronic alcohol use disorder is found to have hepatomegaly and mildly elevated transaminases on routine screening. She is asymptomatic with no clinical signs of cirrhosis. Which investigation is most appropriate as the next step to assess the degree of hepatic fibrosis and guide management decisions?