Cervical Carcinoma and HPV

A 42-year-old woman with stage IVB cervical carcinoma (metastatic to para-aortic lymph nodes and lung) is deemed unsuitable for concurrent chemoradiation. She has normal renal function and good performance status (ECOG 0). What is the drug of choice for first-line palliative chemotherapy?

A 38-year-old woman presents with stage IB cervical carcinoma (tumor size 4 cm) confirmed on biopsy. She is otherwise healthy with normal renal and hepatic function. What is the drug of choice for concurrent chemoradiation therapy in this patient?

What is the mechanism by which HPV E6 oncoprotein contributes to cervical carcinogenesis?

A 42-year-old woman with stage IB2 cervical squamous cell carcinoma (SCC) is deemed suitable for concurrent chemoradiation therapy. Which agent is the drug of choice for radiosensitization during pelvic radiotherapy?

A 42-year-old woman from rural Maharashtra presents with postcoital bleeding and vaginal discharge for 3 months. She is a multipara (G5P5) with menarche at 14 years and first coitus at 18 years. On speculum examination, a friable, bleeding mass is seen on the cervix. Pap smear shows atypical squamous cells of undetermined significance (ASCUS). HPV testing is positive for HPV-16. Colposcopy-directed cervical biopsy shows invasive squamous cell carcinoma with keratin pearl formation. Which HPV-related molecular event is most directly responsible for malignant transformation in this patient?