Endometrial Carcinoma

A 58-year-old postmenopausal woman presents with abnormal uterine bleeding. Endometrial biopsy reveals grade 1 endometrioid adenocarcinoma confined to the inner half of the myometrium (stage IB). She is medically fit for surgery. What is the drug of choice for adjuvant treatment after total abdominal hysterectomy and bilateral salpingo-oophorectomy?

A 58-year-old postmenopausal woman presents with abnormal uterine bleeding for 3 months. Transvaginal ultrasound shows an endometrial thickness of 12 mm with heterogeneous echotexture. What is the investigation of choice to establish a definitive diagnosis?

A 62-year-old woman with stage IIIC2 endometrial carcinoma (para-aortic lymph node involvement) is being considered for systemic therapy. She has completed surgery and pelvic radiotherapy. She has a performance status of 0 and normal renal and cardiac function. What is the drug of choice for first-line chemotherapy?

A 52-year-old woman from Mumbai presents with postmenopausal bleeding and pelvic pain for 4 months. She has a history of Lynch syndrome (MLH1 mutation). Pelvic MRI shows a large endometrial mass with invasion into the outer myometrium and parametrial involvement. Endometrial biopsy confirms grade 3 adenocarcinoma. She is counseled about staging and adjuvant therapy. Which of the following is the MOST appropriate next step in management?

A 58-year-old postmenopausal woman from rural India presents with abnormal vaginal bleeding for 3 months. On examination, she is obese (BMI 34 kg/m²) and has a blood pressure of 150/95 mmHg. Endometrial biopsy reveals adenocarcinoma. What is the most common risk factor for endometrial carcinoma in this patient?