Neonatal Jaundice

A 3-day-old term neonate born to an O-positive mother presents with clinical jaundice. The mother is O-negative and unsensitized (indirect Coombs test negative at delivery). The infant's total serum bilirubin is 14 mg/dL. Which investigation is most appropriate to confirm hemolytic disease and guide management?

A 3-day-old term Indian neonate born via normal vaginal delivery presents with jaundice. Serum bilirubin is 16 mg/dL. The infant is breastfeeding well, passing stools normally, and has no signs of hemolysis. Weight loss is 7% from birth weight. What is the most appropriate next step in management?

Which of the following is the primary mechanism of unconjugated hyperbilirubinemia in physiological jaundice of the newborn?

A 2-day-old preterm neonate (32 weeks gestation) born to an O Rh-negative mother (previously sensitized) presents with jaundice and hepatosplenomegaly. Serum bilirubin is 10 mg/dL. What is the most common cause of hemolytic disease of the newborn in India?

A 3-day-old male neonate, born to an O-positive mother, presents with jaundice. The infant is exclusively breastfed and has passed meconium twice. Antenatal serology showed the mother is O-positive, antibody screen negative. Postnatal direct antiglobulin test (DAT) is negative. Total serum bilirubin is 18 mg/dL, conjugated bilirubin 0.4 mg/dL. The infant's weight is 3.2 kg (birth weight 3.5 kg). What is the most likely diagnosis?