Pancreatic Cancer

Which of the following is the most common histological type of pancreatic cancer?

A 62-year-old man presents with a 3-month history of painless jaundice, pale stools, and dark urine. He reports progressive weight loss of 8 kg over 2 months and mild epigastric discomfort. On examination, the abdomen is soft with a palpable gallbladder. Laboratory investigations show total bilirubin 12 mg/dL (direct 10 mg/dL), alkaline phosphatase 420 U/L, and ALT 85 U/L. Abdominal ultrasound reveals dilated intrahepatic bile ducts and a hypoechoic lesion in the pancreatic head measuring 3 cm. CT abdomen with contrast shows a hypodense mass in the pancreatic head with involvement of the superior mesenteric vein. What is the most appropriate next step in management?

A 58-year-old woman with a 10-year history of chronic pancreatitis (alcohol-related) presents with new-onset epigastric pain, anorexia, and weight loss of 5 kg over 1 month. CA 19-9 level is 240 U/mL (normal <37). MRI abdomen shows a 2.5 cm hypointense lesion in the pancreatic body with loss of the fat plane between the lesion and the splenic vessels. The patient has good performance status (ECOG 0) and no distant metastases on staging CT. What is the most appropriate treatment strategy?

A 58-year-old man with chronic pancreatitis and a 40 pack-year smoking history presents with painless jaundice and weight loss. Imaging shows a 3 cm mass in the pancreatic head. What is the most common site of origin within the pancreas for adenocarcinoma in this patient?

What is the most common histological type of pancreatic cancer?