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    Subjects/Dermatology/Acanthosis Nigricans
    Acanthosis Nigricans
    hard
    hand Dermatology

    A 48-year-old Indian man with a 10-year history of type 2 diabetes presents with velvety, hyperpigmented plaques over the neck and axillae. He is on metformin and glibenclamide. Recent investigations: fasting glucose 156 mg/dL, HbA1c 8.1%, fasting insulin 32 mIU/L. On skin examination, the plaques have exaggerated skin markings and are non-pruritic. There are no oral mucosal lesions. Abdominal imaging is unremarkable. Which of the following interventions is most likely to improve his acanthosis nigricans?

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