A 58-year-old man with diabetes mellitus is admitted with septic shock following a urinary tract infection. His serum creatinine rises from 1.2 to 4.8 mg/dL over 48 hours. Urine microscopy shows muddy brown casts and epithelial cell casts. Which histopathological feature best distinguishes acute tubular necrosis (ATN) from acute interstitial nephritis (AIN)?

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