Risk of malignancies Management Simple Hyperplasia without Atypia- 1% Complex Hyperplasia without Atypia- 3% Progestin Therapy Simple Hyperplasia with Atypia- 8% Complex Hyperplasia without Atypia - 29% Hysterectomy Hysterectomy is the best treatment at any age with atypical endometrial hyperplasia because of the risk of invasive cancer.
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