It is seen in Systemic Sclerosis (Scleroderma). Limited form of scleroderma known as CREST syndrome is characterised by presence of anti-centromere antibodies positive and generalized form shows anti-topoisomerase antibodies Anti-histone antibodies are positive in drug-induced lupus. Anti-SS-A (RO) antibodies and anti-SS-B(LA) antibodies are positive in Sjogren's Syndrome. Most specific in SLE: anti ds-DNA and Anti-Smith antibodies
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