Apoptosis is genetically regulated, hence apoptosis is sometimes referred to as programmed cell death. Plasma membrane remains intact in apoptosis hence there is no leakage of enzymes and inflammation Apoptosis cause activation of caspase and protease which cause cells to shrink . Hence organelle swelling is not a feature of apoptosis. It is a feature of reversible cell injury or necrosis Characteristic feature of apoptosis microscopically is chromatin condensation
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