Neuromuscular blocking agents (NMBAs), particularly rocuronium and suxamethonium, are consistently reported as the most frequent cause of anaphylaxis during general anesthesia in many countries, including Europe and Australia. While latex, antibiotics (especially beta-lactams), and colloids (e.g., gelatins, dextrans) can also cause anaphylaxis, NMBAs typically account for the largest proportion of cases.
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