## Antenatal Screening Package in India India's ANC guidelines include selective infectious disease screening and targeted metabolic screening. The key distinction is between **universal screening** (offered to all) and **risk-based screening** (offered based on risk factors). ### Universal Screening Components in ANC **Key Point:** All pregnant women in India should be screened for: 1. **Syphilis** — RPR/VDRL at first visit and repeat at third trimester - Prevents congenital syphilis and adverse pregnancy outcomes - Cost-effective and simple point-of-care test available 2. **HIV** — Rapid test at first contact; repeat at 32 weeks if initially negative - Prevents mother-to-child transmission (MTCT) - Allows early antiretroviral therapy initiation - Part of PPTCT (Prevention of Parent-to-Child Transmission) program 3. **Hepatitis B surface antigen (HBsAg)** — at first ANC visit - Identifies carrier mothers; allows neonatal immunoprophylaxis - Prevents vertical transmission - Mandatory under India's MCH guidelines ### Gestational Diabetes Mellitus (GDM) Screening — NOT Universal **High-Yield:** Routine OGTT (oral glucose tolerance test) screening for GDM in **all pregnant women** at 24–28 weeks is **NOT** part of India's standard ANC package for low-risk populations. **Clinical Pearl:** India's approach is **risk-based screening** for GDM: - **Risk factors for GDM screening:** age ≥25 years, BMI ≥25, family history of diabetes, previous GDM, glycosuria, recurrent pregnancy loss, or previous macrosomic baby - **Screening method:** Fasting blood sugar (FBS) or random blood sugar (RBS) in first trimester; if abnormal, proceed to OGTT - **Universal OGTT** is not recommended due to cost and resource constraints in low-resource settings **Warning:** Do not confuse "risk-based screening" with "no screening." GDM screening is performed, but selectively based on maternal risk factors, not universally in all pregnant women. ### Comparison: Universal vs. Risk-Based Screening in ANC | Condition | Screening Type | Method | Timing | | --- | --- | --- | --- | | **Syphilis** | Universal | RPR/VDRL | 1st visit + 3rd trimester | | **HIV** | Universal | Rapid test | 1st contact + 32 weeks | | **HBsAg** | Universal | Serology | 1st visit | | **GDM** | Risk-based | FBS/RBS → OGTT if abnormal | 1st trimester (risk assessment) | | **Anemia** | Universal | Hemoglobin | 1st + 3rd trimester | ### Mnemonic: Universal ANC Screening in India **"SHH" — Syphilis, HIV, Hepatitis B** (all universal) GDM is screened based on risk factors, not universally.
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