Apoptosis — Intrinsic and Extrinsic Pathways MCQ — NEET PG Practice Question | NEETPGAI
Apoptosis — Intrinsic and Extrinsic Pathways
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microscope Pathology
A 52-year-old man with newly diagnosed acute myeloid leukemia (AML) presents to the haematology clinic. Cytogenetic analysis shows t(15;17) translocation with PML-RARA fusion gene. Flow cytometry confirms abnormal myeloid blasts. The attending physician explains that the leukemic cells have defective apoptosis due to aberrant PML-RARA protein blocking mitochondrial outer membrane permeabilization. Which is the most appropriate immediate next step in management to restore apoptosis and induce differentiation in these leukemic blasts?
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