A 52-year-old man with acute myocardial infarction (anterior wall STEMI) presents to the emergency department 3 hours after symptom onset. Cardiac biomarkers show elevated troponin I. The pathophysiological process involves cardiomyocyte death through both necrosis and apoptosis. Which drug has been shown to reduce apoptosis-mediated cardiomyocyte loss and improve left ventricular remodeling in acute MI?