A 52-year-old man from Delhi presents with severe epigastric pain radiating to the back, accompanied by nausea and vomiting for the past 6 hours. He has a 10-year history of alcohol abuse. On examination, he is febrile (38.2°C) and has epigastric tenderness. Serum amylase is 1200 U/L (normal <100), lipase 1800 U/L, and triglycerides 450 mg/dL. Abdominal ultrasound shows a normal gallbladder with no stones. Which of the following mechanisms best explains the elevated pancreatic enzyme levels in this patient?