Glycogen synthesis and breakdown takes place in the same cell, having enzymes necessary for both the pathways. Why the glucose-6-phosphate, freshly synthesized during glycogenesis in cytoplasm of hepatocytes, is not immediately degraded by the enzyme glucose!6-phosphatase?

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B. Glucose-6-phosphatase is present in the endoplasmic reticulum and cannot act on glycogen formed in the cytoplasm. Ans: B. Glucose-6-phosphatase is present in the endoplasmic reticulum and cannot act on glycogen formed in the cytoplasm(Ref Harper 30/e p178)Glucose-6-phosphate:Formed in cytoplasm of hepatocytes.Glucose-6-phosphatase:Present in lumen of smooth endoplasmic reticulum of cell.Reaction does not take place until gluconeogenesis is ored.Glucose-6-phosphatase catalyzes hydrolysis of glucose-6-phosphate in liver - Expos glucose a increases blood glucose concentration

Answer

A. The thermodynamics does not or such a reaction to occur

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C. Glycogenesis and glycogenolysis are tightly regulated such that enzymes of only one of those is present at a time.

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D. Steric hindrance due to albumin

Glycogen synthesis and breakdown takes place in the same cell, having enzymes necessary for both the pathways. Why the glucose-6-phosphate, freshly synthesized during glycogenesis in cytoplasm of hepatocytes, is not immediately degraded by the enzyme glucose!6-phosphatase?

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Glycogen synthesis and breakdown takes place in the same cell, having enzymes necessary for both the pathways. Why the glucose-6-phosphate, freshly synthesized during glycogenesis in cytoplasm of hepatocytes, is not immediately degraded by the enzyme glucose!6-phosphatase?

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