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Subjects/Biochemistry/Biochemistry
Biochemistry
medium
flask-conical Biochemistry

An infant presented to the OPD with a history of vomiting and malnutrition. On investigation, the Guthrie test was found to be positive.All are true regarding this disease except?

A. Due to Phenylalanine hydroxylase enzyme defect
B. White patch of hair due to tryptophan deficiency
C. Phenyl acetate positive in urine
D. Mental retardation is present

Explanation

Ans: B. White patch of hair due to tryptophan deficiencyThe deficiency of phenylalanine hydroxylase is the cause of this disease.The genetic mutation may be such that either the enzyme is not synthesized, or a non-functional enzyme is synthesized.The classical Phenylketonuria child is mentally retarded with an IQ of 50.Guthrie test is a rapid screening test.Ferric chloride test: The urine of the patient contains phenyl ketones about 500-3000 mg/day.This could be detected by adding a drop of ferric chloride to the urine.A transient blue-green colour is a positive test.

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