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Subjects/Biochemistry/Biochemistry
Biochemistry
medium
flask-conical Biochemistry

Thiamine is a cofactor for all of the following enzymes except:

A. Alpha ketoglutarate dehydrogenase
B. Branched-chain keto-acid dehydrogenase
C. Succinate dehydrogenase
D. Pyruvate dehydrogenase.

Explanation

Ans: C. Succinate dehydrogenaseThiamin as coenzyme:Catalyzes oxidative decarboxylation reactions.3 multi-enzyme complexes catalyzing oxidative decarboxylation reactions:Branched-chain ketoacid dehydrogenase - Involved in metabolism of leucine, isoleucine & valineAlpha-ketoglutarate dehydrogenase - In citric acid cyclePyruvate dehydrogenase - In carbohydrate metabolismTransketolase reaction - In pentose phosphate pathway.Succinate dehydrogenase:Involved in redox reaction catalyzed by FMN & FAD.

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