A 28-year-old man with a 2-week history of severe thrombocytopenia (platelet count 8,000/μL), petechiae, and mucosal bleeding is evaluated. Bone marrow shows abundant megakaryocytes. Which single feature best distinguishes immune thrombocytopenic purpura (ITP) from thrombotic thrombocytopenic purpura (TTP) in this presentation?

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