A 7-year-old child presents with fever, localized pain, and swelling in the mid-shaft of the tibia. Radiographs show a lytic lesion with an 'onion-skin' periosteal reaction. Biopsy reveals small round blue cells. Which genetic translocation is most commonly associated with this tumor?

Question

Accepted Answer

B. B. t(11;22). The clinical picture of a child with fever, pain, and swelling in the diaphysis of a long bone, along with an 'onion-skin' periosteal reaction and small round blue cells on histology, is classic for Ewing sarcoma. Ewing sarcoma is characterized by the EWS-FLI1 fusion gene, resulting from a specific chromosomal translocation, t(11;22)(q24;q12). t(9;22) is associated with Chronic Myeloid Leukemia (Philadelphia chromosome). t(12;16) is associated with Myxoid Liposarcoma. t(X;18) is associated with Synovial Sarcoma.

Answer

A. A. t(9;22)

Answer

C. C. t(12;16)

Answer

D. D. t(X;18)

A 7-year-old child presents with fever, localized pain, and swelling in the mid-shaft of the tibia. Radiographs show a lytic lesion with an 'onion-skin' periosteal reaction. Biopsy reveals small round blue cells. Which genetic translocation is most commonly associated with this tumor?

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A 7-year-old child presents with fever, localized pain, and swelling in the mid-shaft of the tibia. Radiographs show a lytic lesion with an 'onion-skin' periosteal reaction. Biopsy reveals small round blue cells. Which genetic translocation is most commonly associated with this tumor?

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