The key features here are the age group (young adult), the epiphyseal location (distal radius, extending to subchondral bone), the purely lytic nature of the lesion, and the presence of multinucleated giant cells on histology. These are all characteristic of a Giant Cell Tumor (GCT) of bone. GCTs are benign but locally aggressive tumors. Osteoid osteoma is a small, painful lesion with a central nidus, typically in the cortex of long bones. Enchondroma is a benign cartilage tumor, usually found in the metaphysis or diaphysis of small bones of the hands and feet. Fibrous dysplasia is a developmental anomaly where normal bone is replaced by fibrous tissue and immature woven bone, often presenting as a 'ground-glass' appearance.
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