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Subjects/Dermatology/Bullous Pemphigoid
Bullous Pemphigoid
medium
hand Dermatology

The autoantibodies in Bullous Pemphigoid are primarily directed against which of the following components of the dermal-epidermal junction?

A. A. Desmoglein 1 and 3
B. B. Collagen VII
C. C. BP180 (Type XVII collagen) and BP230 (Plectin)
D. D. Transglutaminase

Explanation

Bullous Pemphigoid is characterized by autoantibodies targeting two hemidesmosomal proteins: BP180 (also known as Type XVII collagen) and BP230 (a plakin family protein, plectin). Desmoglein 1 and 3 are the target antigens in Pemphigus Vulgaris. Collagen VII is the target antigen in Epidermolysis Bullosa Acquisita. Transglutaminase (specifically tissue transglutaminase) is the autoantigen in Dermatitis Herpetiformis and Celiac Disease.

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