Histopathology of Bullous Pemphigoid characteristically shows a subepidermal blister, meaning the blister forms below the epidermis, separating it from the dermis. A prominent inflammatory infiltrate, rich in eosinophils, is typically seen within the blister cavity and the superficial dermis. Intraepidermal acantholytic blister with tombstone cells is characteristic of Pemphigus Vulgaris. A subcorneal pustule with neutrophils is seen in conditions like subcorneal pustular dermatosis (Sneddon-Wilkinson disease) or pustular psoriasis. Dermal edema with spongiosis and exocytosis is typical of eczematous dermatitis.
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