For generalized Bullous Pemphigoid, systemic corticosteroids (e.g., oral prednisone) are considered the first-line treatment to control disease activity and promote healing. High-potency topical corticosteroids can be used for localized disease or as an adjunct to systemic therapy, but are insufficient for generalized cases. Dapsone is primarily used for Dermatitis Herpetiformis. Rituximab is a B-cell depleting agent and is typically reserved for severe, refractory cases of Bullous Pemphigoid or as a steroid-sparing agent, not as a first-line therapy.
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