Nystatin oral suspension is the first-line topical treatment for oral candidiasis (thrush) in infants and adults. It is applied directly to the lesions in the mouth. Oral fluconazole is a systemic antifungal reserved for more severe or refractory cases, or in immunocompromised patients. Topical miconazole cream is formulated for skin application and is not suitable for oral use. Griseofulvin is an oral antifungal primarily used for dermatophyte infections (e.g., tinea) and is ineffective against *Candida* species.
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