A 52-year-old Indian male presents to the cardiology clinic with a 6-month history of progressive exertional chest pain. His lipid profile shows total cholesterol 320 mg/dL, LDL 240 mg/dL, HDL 28 mg/dL, and triglycerides 380 mg/dL. He is started on atorvastatin 40 mg daily. After 4 weeks, repeat lipid panel shows total cholesterol 280 mg/dL and LDL 180 mg/dL, with only modest improvement. His liver function tests and creatine kinase are normal. Which of the following mechanisms best explains the incomplete response to statin therapy in this patient?