Chronic Myeloid Leukemia (CML) is characterized by a specific reciprocal translocation between chromosome 9 and chromosome 22, denoted as t(9;22)(q34;q11). This translocation results in the formation of the Philadelphia chromosome and the BCR-ABL fusion gene, which produces a constitutively active tyrosine kinase driving the proliferation of myeloid cells. Option B, t(8;14)(q24;q32), is associated with Burkitt lymphoma. Deletion of 13q is seen in some B-cell chronic lymphocytic leukemias and retinoblastoma. Trisomy 8 can be seen in some myelodysplastic syndromes and acute myeloid leukemias but is not pathognomonic for CML.
Sign up free to access AI-powered MCQ practice with detailed explanations and adaptive learning.