A 48-year-old woman with primary biliary cholangitis (PBC) presents with progressive pruritus, jaundice, and fatigue. Liver biopsy confirms chronic cholestasis with portal inflammation and bile duct destruction. Alkaline phosphatase is 320 U/L and total bilirubin is 3.2 mg/dL. Which is the drug of choice for slowing disease progression in this patient?

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