Chronic Leukemias MCQ — NEET PG Practice Question | NEETPGAI
Chronic Leukemias
medium
microscope Pathology
A 58-year-old man from Mumbai presents with a 6-month history of progressive fatigue and early satiety. On examination, he has marked splenomegaly (8 cm below the costal margin) and hepatomegaly. His CBC shows: Hb 9.2 g/dL, WBC 185,000/μL with left shift (myelocytes 18%, metamyelocytes 12%, bands 8%, segmented neutrophils 45%, eosinophils 8%, basophils 3%), and platelets 420,000/μL. Bone marrow aspirate shows myeloid hyperplasia with increased eosinophils and basophils. Cytochemistry: MPO positive, PAS negative. Fluorescence in situ hybridization (FISH) reveals t(9;22) with BCR-ABL1 fusion. What is the most likely diagnosis?
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