A 58-year-old man from Delhi presents with fatigue and weight loss for 3 months. On examination, he has splenomegaly. Complete blood count shows WBC 85,000/μL with 60% neutrophils, 15% metamyelocytes, 12% myelocytes, 8% blasts, and mild anemia. Bone marrow aspirate confirms chronic myeloid leukemia (CML) in chronic phase with t(9;22) positive on cytogenetics. The patient is newly diagnosed and has no contraindications to targeted therapy. What is the most appropriate next step in management?