A 48-year-old woman with CKD stage 5 (eGFR 12 mL/min/1.73 m²) on hemodialysis presents with hemoglobin 7.8 g/dL, serum iron studies showing ferritin 450 ng/mL and transferrin saturation 22%, and EPO resistance (on 300 IU/kg/week). What is the drug of choice to improve anemia response in this patient?

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