Active systemic sepsis is an absolute contraindication for corneal donation due to the high risk of transmitting infectious agents to the recipient. Other absolute contraindications include HIV, active viral hepatitis, Creutzfeldt-Jakob disease, active ocular infection, and certain systemic malignancies with ocular metastasis (e.g., retinoblastoma, leukemia, lymphoma). Diabetes mellitus, age over 75 years, and previous cataract surgery are generally not absolute contraindications for corneal donation, although older age or certain systemic conditions might affect the quality of the donor tissue or require careful evaluation.
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