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    Subjects/Medicine/Dermatology
    Dermatology
    medium
    stethoscope Medicine

    The clinical image shows a chronic inflammatory condition affecting the posterior scalp and nuchal region. Which of the following is a common associated finding in patients with this condition?

    A. Splenomegaly
    B. Reactive cervical lymphadenopathy
    C. Generalized lymphadenopathy
    D. Hepatosplenomegaly

    Explanation

    Image Findings

    Multiple firm papules and nodules: Located on the posterior scalp and nuchal region, extending into the hairline. Follicular involvement: Many lesions appear to be centered around hair follicles. Coalescence: Some papules and nodules have coalesced to form larger, irregular plaques. Scarring and hypopigmentation: Evidence of chronic inflammation with areas of scarring and altered pigmentation. Alopecia:* Hair loss is visible within the affected scarred areas.

    Diagnosis

    Key Point
    The image displays classic features of Acne Keloidalis Nuchae (AKN), a chronic inflammatory condition of the hair follicles on the posterior scalp and neck.

    AKN, also known as folliculitis keloidalis nuchae, is characterized by chronic inflammation of the hair follicles, leading to papules, pustules, and eventually keloidal scarring and permanent hair loss (cicatricial alopecia). It is more common in young men with curly hair, particularly those of African descent. The exact etiology is unknown but is thought to involve chronic irritation, ingrown hairs, and a foreign body reaction to hair shaft fragments.

    Differential Diagnosis

    Table
    FeatureAcne Keloidalis Nuchae (AKN)Folliculitis DecalvansDissecting Cellulitis of the ScalpTinea Capitis (Inflammatory)
    LocationPosterior scalp, nuchal regionVertex, crown, occiputVertex, occiput, diffuseAny scalp area
    Primary LesionsFirm papules, nodules, keloidal scarsPustules, erosions, crusts, tufted hairsBoggy nodules, interconnected sinuses, purulent dischargeErythematous, scaly patches, pustules, kerion
    ScarringProminent keloidal scarring, cicatricial alopeciaCicatricial alopeciaExtensive scarring, sinus tractsVariable, can cause scarring alopecia (kerion)
    Associated LymphReactive cervical lymphadenopathy (if severe/infected)May have reactive lymphadenopathyMay have reactive lymphadenopathyReactive lymphadenopathy (especially with kerion)
    HairPermanent hair loss in affected areasTufted hairs (multiple hairs emerging from one follicle)Permanent hair loss, often with purulent dischargeBroken hairs, black dots, scaling, sometimes kerion

    Clinical Relevance

    Clinical Pearl
    While AKN is primarily a dermatological condition, the chronic inflammation and potential for secondary bacterial infection can lead to reactive cervical lymphadenopathy. This indicates the body's immune response to the localized inflammation or infection.

    High-Yield for NEET PG

    High-YieldNEET PG
    Acne Keloidalis Nuchae is a common cause of cicatricial alopecia in men, particularly those with curly hair. Reactive cervical lymphadenopathy is an important associated finding to look for during physical examination, especially in severe or secondarily infected cases.
    Key Point
    The characteristic "cobblestone" appearance due to coalescing keloidal papules and plaques on the nuchal scalp is pathognomonic for AKN.

    Common Traps

    Warning
    Do not confuse reactive cervical lymphadenopathy with generalized lymphadenopathy. Reactive lymphadenopathy in AKN is typically localized to the cervical region, reflecting a response to the local inflammatory process, rather than a systemic disease.

    Reference

    Bolognia, Jean L., et al. Dermatology. 4th ed., Elsevier, 2018, Ch 71, p. 1205-1206

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