Griseofulvin is a fungistatic agent that is concentrated in keratin-containing tissues (skin, hair, nails), making it highly effective for dermatophyte infections, especially tinea capitis. It is considered the traditional first-line oral treatment for tinea capitis, particularly in children. While terbinafine is also effective and often used, griseofulvin has a long history of safe and effective use in pediatric tinea capitis. Nystatin is primarily used for Candida infections and is not effective against dermatophytes. Fluconazole can be used for dermatophyte infections but is not typically first-line for tinea capitis. Amphotericin B is a broad-spectrum antifungal reserved for severe systemic fungal infections and is not used for superficial dermatophyte infections.
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