A 42-year-old woman from Kolkata presents with a 2-month history of fever, right upper quadrant pain, and hepatomegaly. Ultrasound shows a 6 cm hypoechoic lesion in the right lobe of the liver with no internal septations. Stool microscopy is negative for parasites. Serology (IHA/ELISA) for E. histolytica is positive. What is the most appropriate next step in management?

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