A 35-year-old man from Mumbai is found to have HBsAg positivity on routine screening. His serology shows: HBsAg (+), anti-HBs (−), HBeAg (+), anti-HBe (−), anti-HBc IgM (−), anti-HBc IgG (+). Which serological marker best distinguishes acute hepatitis B from chronic hepatitis B in this patient?

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