A 48-year-old man with a 15-year history of intravenous drug use presents with fatigue, jaundice, and right upper quadrant pain. He reports no previous hepatitis vaccination. Laboratory findings: HBsAg positive, Anti-HBc positive (total), Anti-HBc IgM negative, Anti-HBs negative, HBeAg positive, HBV DNA 2.5 × 10^6 IU/mL. Liver biopsy shows bridging fibrosis with portal-based inflammation and scattered acidophil bodies. Abdominal ultrasound reveals a nodular liver contour. What is the most likely diagnosis?