## National Immunisation Schedule — IPV Administration **Key Point:** The first dose of IPV is administered at 6 weeks of age as part of the primary immunisation series under the NIS. ### IPV Dosing Schedule (NIS 2023) | Age | Vaccine | Route | Dose | | --- | --- | --- | --- | | **6 weeks** | IPV-1 | IM/SC | 0.5 mL | | **10 weeks** | IPV-2 | IM/SC | 0.5 mL | | **14 weeks** | IPV-3 | IM/SC | 0.5 mL | | **18–24 months** | IPV booster | IM/SC | 0.5 mL | **High-Yield:** IPV is given at 6, 10, and 14 weeks (primary series) followed by a booster at 18–24 months. This schedule ensures early protection against all three poliovirus serotypes. **Clinical Pearl:** IPV replaced OPV in the primary series under the NIS to reduce vaccine-derived poliovirus (VDPV) risk, while OPV continues as boosters in pulse polio campaigns for mucosal immunity. ### Why 6 Weeks? - Maternal antibodies have declined sufficiently to allow immune response - Early protection against wild poliovirus in endemic regions - Aligns with other primary immunisations (DPT, Hepatitis B) [cite:IAP Immunisation Schedule 2023]
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