## National Immunisation Schedule — IPV Timing **Key Point:** The first dose of IPV is administered at **6 weeks of age** as part of the primary immunisation series under the NIS. ### IPV Dosing Schedule (NIS 2024) | Age | Vaccine | Route | Dose | | --- | --- | --- | --- | | 6 weeks | IPV (1st dose) | Intramuscular | 0.5 mL | | 10 weeks | IPV (2nd dose) | Intramuscular | 0.5 mL | | 14 weeks | IPV (3rd dose) | Intramuscular | 0.5 mL | | 18–24 months | IPV (Booster) | Intramuscular | 0.5 mL | **High-Yield:** The NIS follows a **6-10-14 week schedule** for the three primary doses of IPV, with a booster at 18–24 months. This is distinct from the OPV schedule (which uses 6-10-14 weeks + 18-24 months booster) and reflects the global shift toward IPV to eliminate wild poliovirus and reduce vaccine-derived poliovirus (VDPV) risk. **Clinical Pearl:** India transitioned to a predominantly IPV-based schedule to achieve polio eradication certification. The combination of IPV (inactivated) and OPV (oral) in a sequential schedule maximizes mucosal and systemic immunity while minimizing VDPV transmission.
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