The clinical presentation of chronic inflammatory back pain (worse in the morning, improving with activity) in a young male is highly suggestive of ankylosing spondylitis, a seronegative spondyloarthropathy. Acute anterior uveitis (iritis) is the most common extra-articular manifestation of ankylosing spondylitis, affecting about 25-40% of patients and causing eye redness, pain, and photophobia. Rheumatoid nodules are characteristic of rheumatoid arthritis. Psoriatic skin lesions are seen in psoriatic arthritis. Subcutaneous tophi are pathognomonic for chronic gout.
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