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    Subjects/ENT/Laryngeal Carcinoma
    Laryngeal Carcinoma
    medium
    ear ENT

    A 58-year-old male smoker presents with a 3-month history of progressive hoarseness and dysphagia. On laryngoscopy, a left vocal cord lesion is seen. Biopsy confirms squamous cell carcinoma. CT chest and abdomen are normal. What is the most appropriate next step in management?

    A. Neoadjuvant chemotherapy followed by radiation
    B. Transoral laser microsurgery (TLM) for early-stage disease assessment and treatment
    C. Palliative radiotherapy alone
    D. Radical laryngectomy with bilateral neck dissection

    Explanation

    ## Clinical Assessment This patient presents with a **vocal cord lesion confirmed as squamous cell carcinoma** with no distant metastases on staging imaging. The key clinical feature is that the lesion is **localized to the vocal cord** (early-stage disease). ## Management Algorithm for Early Laryngeal Carcinoma ```mermaid flowchart TD A[Laryngeal SCC diagnosed]:::outcome --> B{Stage?}:::decision B -->|Early stage<br/>T1-T2, N0| C[Transoral laser<br/>microsurgery TLM]:::action B -->|Locally advanced<br/>T3-T4 or N+| D[Concurrent chemoRT<br/>or laryngectomy]:::action C --> E[Voice preservation<br/>Single modality]:::outcome D --> F{Resectable?}:::decision F -->|Yes| G[Laryngectomy ±<br/>neck dissection]:::action F -->|No| H[Concurrent chemoRT]:::action ``` ## Why TLM is the Next Step **Key Point:** For **T1–T2 vocal cord carcinomas** (early stage, no nodal involvement), transoral laser microsurgery is the gold standard first-line treatment. It offers: 1. **Single-modality cure** — complete excision with histologic margins in one procedure 2. **Voice preservation** — maintains laryngeal function better than radiotherapy 3. **Outpatient feasibility** — shorter hospital stay, faster recovery 4. **No long-term toxicity** — avoids radiation side effects (xerostomia, late stenosis) 5. **Salvage options preserved** — if recurrence occurs, radiation or repeat surgery remains available **High-Yield:** TLM is preferred over external beam radiation for **early vocal cord cancers** because it achieves equivalent cure rates (85–95% local control) with superior functional outcomes [cite:Robbins 10e Ch 16]. **Clinical Pearl:** The absence of nodal disease (N0 on imaging) and the localized nature of the lesion make this a candidate for organ-preservation surgery rather than laryngectomy. ## Why Other Options Are Incorrect See distractor analysis below. ![Laryngeal Carcinoma diagram](https://mmcphlazjonnzmdysowq.supabase.co/storage/v1/object/public/blog-images/explanation/14554.webp)

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