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Subjects/Pathology/Lymphomas
Lymphomas
easy
microscope Pathology

Which of the following statements regarding Diffuse Large B-cell Lymphoma (DLBCL) is TRUE?

A. A. It is typically an indolent lymphoma with a good prognosis without treatment.
B. B. It is characterized by the t(14;18) translocation in the majority of cases.
C. C. It is the most common type of aggressive Non-Hodgkin Lymphoma.
D. D. It primarily affects T-cells and is CD3 positive.

Explanation

Diffuse Large B-cell Lymphoma (DLBCL) is indeed the most common type of aggressive Non-Hodgkin Lymphoma, accounting for approximately 30-40% of adult NHLs. It is an aggressive lymphoma that requires prompt treatment, unlike indolent lymphomas. The t(14;18) translocation is characteristic of Follicular Lymphoma, although a subset of DLBCLs can also harbor this translocation. DLBCL is a B-cell lymphoma, meaning it is typically CD20 positive, not CD3 positive (which is a T-cell marker).

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