A 28-year-old Ashkenazi Jewish woman presents with progressive hepatosplenomegaly, bone pain in the left hip, and recent pancytopenia (Hb 9.2 g/dL, platelets 85,000/μL). Bone marrow aspirate reveals lipid-laden macrophages with a characteristic "crumpled tissue paper" appearance. Imaging of the femur shows the classic "Erlenmeyer flask" deformity of the distal femur. The enzyme deficiency responsible for this presentation is the structure marked **B** in the diagram. Which of the following best describes the primary biochemical consequence of this enzyme deficiency?