Phenelzine is a classic example of an irreversible, non-selective monoamine oxidase inhibitor (MAOI). It inhibits both MAO-A and MAO-B enzymes, leading to increased levels of serotonin, norepinephrine, and dopamine in the synaptic cleft. This broad inhibition contributes to its antidepressant effects but also to its significant side effect profile and drug/food interactions.
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